The company Moderna said a test in 8 healthy volunteers found its experimental vaccine was safe and provoked a strong immune response. it is on an accelerated timetable to being larger human trials soon.
The first coronavirus vaccine to be tested in people appears to be safe and able to stimulate an immune response against the infection, the manufacturer, Moderna, announced on Monday, offering a glint of hope to a world desperate for ways to stop the pandemic.
Phase 1 trial result of the vaccine, mRNA-1273, has been found promising. a look at what the vaccine is composed of and how it works, what the trials showed, and what are the many stages that remain.
On Monday, US stock markets went soaring on the back of promising results from a vaccine against novel coronavirus disease COVID-19 developed by the US pharmaceutical company Moderna. A look at the mRNA-1273 vaccine and how so much hope has been pinned on it.
WHAT IS mRNA-1273?
It is the working name of Moderna’s vaccine, which is currently on phase 1 clinical trials under the aegis of the US National Institute of Allergy and infection disease (NIAID), a part of the US National Institutes of Health(NIH) and led by Dr. Anthony Fauci.
The mRNA in the name means messenger RNA, which carries the genetic formula for the coding of a specific protein. in this vaccine, the particular mRNA used codes for the most distinguishing features of the SARS-CoV2—The spike protein— which us also the appendage that the virus uses to enter the cell and replicate. The vaccine has injected into a person, codes for the spike protein. even without the introduction of an attenuated (recognizable but not harmful) virus into the body, the body learns what the virus looks like and arms itself with the antibodies that are required to act against it.
PROMOTING RESULT OF MODERNA
Moderna had announced that the mRNA, on entering the body, had managed to show a degree of the immune response in the first eight patients. Tal Zaks, Moderna chief medical officer. Told the financial times that the result showed that even lower doses elicited an “immune response of the magnitude caused by natural infection, this data substantiate our belief that mRNA-1273 has the potential to prevent COVID-19 Disease he said. among the side-effects that were noted were chills and little redness in the place where the injection had been given.
The participants received two doses of the vaccine, different doses were used to testing the potency of the vaccine, Two weeks after the second dose, even those on the lowest does show enough antibodies two raise hopes of being able two thwart an infection. it was the same level of protection that people who have recovered from the infections show. The group that got a higher dose had higher level.